<ArticleSet>
<Article>
<Journal>
<PublisherName>Pharmaceutical and Biological Evaluations</PublisherName>
<JournalTitle>Pharmaceutical and Biological Evaluations</JournalTitle>
<Issn>2394-0859</Issn>
<Volume>3</Volume>
<Issue>3</Issue>
<PubDate>
<Year>2016</Year>
<Month>06</Month>
<Day>11</Day>
</PubDate>
</Journal>
<ArticleTitle>Formulation and evaluation of bioadhesive drug delivery system</ArticleTitle>
<FirstPage>377</FirstPage>
<LastPage>387</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>Asif</FirstName>
<LastName>Pathan</LastName>
<Affiliation>Oriental College of Pharmacy, Sanpada, Navi Mumbai 400705, India. asifpathan51@gmail.com</Affiliation>
</Author>
<Author>
<FirstName>Asish</FirstName>
<LastName>Dev</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2016</Year>
<Month>04</Month>
<Day>29</Day>
</PubDate>
<PubDate>
<Year>2016</Year>
<Month>05</Month>
<Day>17</Day>
</PubDate>
<PubDate>
<Year>2016</Year>
<Month>05</Month>
<Day>05</Day>
</PubDate>
</History>
<Abstract>Objective: The objective of the work is to formulate gliclazide bioadhesive tablets that will significantly improve the availability of the drug especially under the situations of prolonged use of drug and also reduce the total dosage of administered drug and consequently reduce the side effects. All these factors will ultimately lead to enhanced patient compliance and patient care.Methods: Various natural and semi synthetic polymers were screened and they were selected on the basis of their swelling and gelling properties. The formulated batches were subjected to various evaluation parameters and optimization was done.Results: The F7 batch was concluded to be the best batch in which Xanthan gum (70%) and HPMC K4M (30%) were taken. Stability studies of the optimized batches were conducted as per the ICH guidelines.Conclusions: From this study it was concluded that as the thickness of tablet increases the hardness of tablet decreases which leads to increase in the swelling of the tablet and hence the increase in the drug release.</Abstract>
<ObjectList>
<Object>
<Param>Gliclazide, Antidiabetic drug, Bioadhesive tablets, Swelling index</Param>
</Object>
</ObjectList>
<URLs>

Abstract

<Fulltext>
<pdf>http://onlinepbe.com/index.php/PBE/article/view/126/pdf33</pdf>
</Fulltext>
</URLs>
</Article>
</ArticleSet>

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