Phytochemical and anticarcinogenic evaluation of triphala powder extract, against melanoma cell line induced skin cancer in rats

Nikhlesh Birla, Prabhat K. Das


Objective: Triphala is a botanical preparation consists of Terminalia chebula, Emblica officinalis, Terminalia bellerica and it exhibits a number of health benefits, including antioxidant activity, lowers cholesterol, inhibits HIV, Reduces tumors in animals, protects and improves liver function and many more. Triphala (Harad, Bahada and Amala) in different ratios exhibits a number of health benefits, including: anti-cancerous, antipyretic, antiulcer, antidiabetic activities. Triphala has historically been used as a digestive aid for constipation. Triphala triggered the cancerous cells to die off and significantly reduced the size of the tumours. This study was carried out to evaluate the effect of triphala powder (hydro alcoholic extract) on melanoma skin cancer in rats.

Methods: The study was carried out on the melanoma cell line (B6F10) induce model.

Results: The powder extract of triphala produced a significant activity in Melanoma cell line-induced skin cancer.

Conclusions: Triphala extract increased healing of melanoma skin cancer and prevented the development of experimentally induced skin cancer in rats.


Triphala, Melanoma, B6F1O, Skin cancer, Hydro alcoholic

Full Text:



Cancer Research UK, cancer incidence statistics by age. Retrieved on 2007-06-25, 2007.

WHO (February 2006). Cancer. World Health Organization. Retrieved on 2007-06-25. 2007.

Jagtap AG, Karkera SG. Potential of aqueous extract of Terminalia chebula as an anticareis Agent. J Ethnopharmacol. 1999;68(1-3):299-306.

OECD Guidelines for the testing of chemical, up and down procedure, adopted 21st September 1998:1-8.

Goyal RK. Practical in Pharmacology, 10th ed. Ahmadabad, S.B. Shah Prakashan; 2010-11: 148-149.

Schrauzer GN. Selenium. Mechanistic aspects of anticarcinogenic action. Biol Trace Elem Res. 1992;33:51-62.

Wei H, Frenkel K. In vivo formation of oxidized DNA base in tumor promoter-treated mouse skin. Cancer Res. 1991;51(16):4443-9.

Sandhya T, Lathika KM, Pandey BN, Mishra KP. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett. 2006;231(2):206-14.

Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. The in vitro cytotoxic and apoptotic activity of Triphala-an Indian herbal drug. J Ethnopharmacol. 2005;97(1):15-20.

Inoue M, Sakaguchi N, Isuzugawa K, Tani H, Ogihara Y. Role of reactive oxygen species in gallic acid-induced apoptosis. Biol Pharm Bull. 2000;23(10):1153-7.


  • There are currently no refbacks.

Copyright (c) 2016 Pharmaceutical and Biological Evaluations

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License


© Copyright 2018 - Pharmaceutical and Biological Evaluations