<ArticleSet>
<Article>
<Journal>
<PublisherName>Pharmaceutical and Biological Evaluations</PublisherName>
<JournalTitle>Pharmaceutical and Biological Evaluations</JournalTitle>
<Issn>2394-0859</Issn>
<Volume>4</Volume>
<Issue>2</Issue>
<PubDate>
<Year>2017</Year>
<Month>04</Month>
<Day>02</Day>
</PubDate>
</Journal>
<ArticleTitle>Antifungal potential of improved crude extracts of Mitracarpus scaber (Zucc) against Candida guilliermondii and Candida parapsilosis</ArticleTitle>
<FirstPage>90</FirstPage>
<LastPage>96</LastPage>
<Language>EN</Language>
<AuthorList>
<Author>
<FirstName>E.</FirstName>
<MiddleName>K.</MiddleName>
<LastName>Kporou</LastName>
<Affiliation>Biochemistry and Microbiology Laboratory, Bioactives natural Substances Unit, UFR Agroforestery Faculty, Jean Lorougnon Guede University, BP 150, Daloa Pharmacodynamics biochemical Laboratory, UFR Biosciences, Felix Houphouet Boigny University, BP 582 Abidjan. elykoua@yahoo.fr</Affiliation>
</Author>
<Author>
<FirstName>C.</FirstName>
<LastName>Ibourahema</LastName>
</Author>
<Author>
<FirstName>A.</FirstName>
<MiddleName>J.</MiddleName>
<LastName>Ackah</LastName>
</Author>
<Author>
<FirstName>S.</FirstName>
<LastName>Ouattara</LastName>
</Author>
</AuthorList>
<History>
<PubDate>
<Year>2017</Year>
<Month>03</Month>
<Day>02</Day>
</PubDate>
<PubDate>
<Year>2017</Year>
<Month>03</Month>
<Day>16</Day>
</PubDate>
</History>
<Abstract>Objective: The present study was undertaken to evaluate antifungal potential of improved crude extracts of Mitracarpus scaber Zucc., an ivorian traditional medicinal plant against two species of clinical yeast isolates: Candida parapsilosis and Candida guilliermondii.Methods: For evaluation of antifungal activity, double dilution method in slope tubes was used. Crude extracts of M. scaber were prepared by extracting with a blender in aqueous and hydroalcohol. In first; Aqueous (XAq) and Hydroalcoholic (X0) extracts were evaluated, and secondary the crude extract X0 was improved by partition in mixture of aqueous and hexanic solvent 50:50 v/v. Each dried phase was also examined. A phytochemical screening has been performed on most active extracts.Results: In vitro antifungal activity showed that crude extract X0 was the most active with MIC = 6.25 mg/ml. Among the extracts obtained by partition from extract X0, extract X11 (Hexanic phase) was the better with lowest antifungal parameters MIC and MFC range between 1.562 mg/ml and 0.781 mg/ml and IC50 range between 0.73 mg/ml to 0.598 mg/ml. In addition, the most active extract contained only terpens and steroids.Conclusions: Antifungal activity of M. scaber was improved by partition of an hydroalcoholic extract (X0) in mixture hexane-water 50:50 v/v. Hexanic phase (X11) was more active against C. parapsilosis and C. guilliermondii.</Abstract>
<ObjectList>
<Object>
<Param>Mitracarpus scaber, Antifungal, Performed extract</Param>
</Object>
</ObjectList>
<URLs>

Abstract

<Fulltext>
<pdf>http://onlinepbe.com/index.php/PBE/article/view/219/pdf</pdf>
</Fulltext>
</URLs>
</Article>
</ArticleSet>

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