A comparative study on effect of polymers on release kinetics glimepiride matrix tablet

Sonia Chowdhury, Mandava Nithin Babu, K. Ankitha, B. Shirisha, Madhurika Sirigadi, Esarapu Kavya

Abstract


Objective: The Present investigation was performed to find out the effect of synthetic and natural polymers on the release properties of glimepiride matrix tablet. Glimepiride is a first third generation sulphonyl urea agent for the treatment of type- II diabetes mellitus. Methocel K15M, Olibanum Gum were used as key release modifying polymers.

Methods: Nine formulations were prepared taking different concentration of natural and synthetic polymers, The drug excipient mixtures were subjected to pre-compression studies. The tablets were prepared by direct compression method; all formulations were subjected to physicochemical studies, in- vitro drug release, kinetic studies and stability studies. The physicochemical results were found within the limits.

Results: FTIR study interpretation did not show any drug–excipient interaction The drug release from the optimized formulation F-7 was extended for a period of 12 hours. The release kinetics of F-7 formulation showed that the release of drug follows zero order models. The optimized formulations were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern.

Conclusions: Results of the present study indicated the suitability of the above mentioned polymers in the preparation of sustained release formulation of Glimepiride for the management of type-II diabetes mellitus effectively.


Keywords


Sustained release, Glimepiride, FTIR

Full Text:

PDF HTML XML

References


Sastry SV, Nyshdham JR, Fix JA. Recent technological advances in oral drug delivery: A review. Pharm Sci and Tech Today. 2000;3:138-45.

Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics, A Treatise. 2010: 335.

Gilbert Banker S. Modern Pharmaceutics, 4th edition, Published by: Marcel Dekker. 2006: 297-321.

Patel R, Baria A. Formulation development and process optimization of theophylline sustained release matrix tablet. Int J of Pharmacy and Pharm Sci. 2009;1(2),30-42.

Rother KI. “Diabetes treatment – bridging the divide”. The New Eng J Med. 2007;15:1499-1501.

Wild S, Roglic G, Gree A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53.

American Diabetes Association. Economic cost of diabetes in the US in 2002. Diabetes Care. 2003;26:917-32.

Sekhar CY, Venu V, Jaganathan K, Selvi SR, Perumal P. Formulation and in-vitro evaluation of sustained release matrix tablets of glimepiride by using natural gums as release modifiers. J Global Trends in Pharm Sci. 2011;2(4):394-403.

Lachman L, Lieberman HA. The theory and practice of industrial pharmacy. Special Indian edition. 2009:293-373.

Remington. 20th edition. The Science and Practice of Pharmacy. Lippincott Williams & Wilkins, Delhi; 2002:903–914.

Jain S, Yadav S, Patil U. Preparation and evaluation of sustained release matrix tablet of furosemide using natural polymers. Research Journal of Pharmacy and Technology. 2008;1(4):374-6.

Augsburger LL, Zellhofer MJ. Tablet formulation. Encyclopedia of Pharmaceutical Technology. 2006:3641-52.

Vazquez MJ, Perez-Marco, Gomez- Amoza JL, Martinez-Pacheco R, Souto C, Concheiro A. Influence of technological variables on drug release of drug from hydrophilic matrices. Drug Dev Ind Pharm. 1992;18:1355-75.

Harland RS, Gazzaniga, A, Sangalli ME, Colombo P, Peppas NA. Drug/polymer matrix swelling and dissolution. Pharm. Res. 1998;5:488-94.

Kannan S, Manivannan R, Ganesan K, Nishad PK, Kumar NS. Formulation and Evaluation of Sustained Release Tablets of Aceclofenac using Hydrophilic Matrix System. Int J PharmTech Res. 2010;2(3):1775-80.




DOI: http://dx.doi.org/10.26510/2394-0859.pbe.2017.16

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Pharmaceutical and Biological Evaluations

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.



Creative Commons License

 

© Copyright 2018 - Pharmaceutical and Biological Evaluations