A review on self-emulsified drug delivery system

Priya Thakare, Vrushali Mogal, Pankaj Borase, Jaydeep Dusane, Sanjay Kshirsagar

Abstract


Improving oral bioavailability of low poorly water soluble drugs using self-emulsifying drug delivery systems (SEDDS) possess significant potential. Oral bioavailability of hydrophobic drugs can be improved using SEDDS, and appears most promising. Their dispersion in gastro intestinal (GI) fluid after administration forms micro or nano emulsified drug which gets easily absorbed through lymphatic pathways bypassing the hepatic first pass metabolism. Parameters like surfactant concentration, oil to surfactant ratio, polarity of emulsion, droplet size and charge on droplet plays a critical role in oral absorption of drug from SEDDS. For hydrophobic drug substances that exhibit dissolution step as rate limiting for absorption, SEDDS offer an improvement in rate and extent of absorption and gives more reproducible plasma concentration time profiles. Use of combined in vitro dispersion and digestion methodologies has enabled a much improved understanding of role of intestinal lipid processing on solubilization behavior of lipid based drug delivery systems (LBDDS). The article gives a brief view on the solid lipid nanoparticles and its evaluation.


Keywords


Self-Emulsifying formulation, Lipid-based drug delivery systems, Characterization, Bioavailability enhancement

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References


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